Showing results for Neuronal HD
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Sensory and behavioral modulation of thalamic head-direction cell...
Head-direction (HD) neurons are thought to exclusively encode directional heading. In awake mice, we found that sensory stimuli evoked robust short-latency responses in thalamic HD cells, but not in n...
Cortical circuit alterations precede motor impairments in Hunting...
Huntington’s disease (HD) is a devastating hereditary movement disorder, characterized by degeneration of neurons in the striatum and cortex. Studies in human patients and mouse HD models suggest that...
Behavioural abnormalities and selective neuronal loss in HD trans...
Huntington disease (HD) is an adult-onset, autosomal dominant inherited human neurodegenerative disorder characterized by hyperkinetic involuntary movements, including motor restlessness and chorea, s...
Differential loss of striatal projection neurons in Huntington di...
Huntington disease (HD) is characterized by the loss of striatal projection neurons, which constitute the vast majority of striatal neurons. To determine whether there is differential loss among diffe...
Serena Yeung-Levy's Profile | Stanford Profiles
Dr. Serena Yeung-Levy is an Assistant Professor of Biomedical Data Science and, by courtesy, of Computer Science and of Electrical Engineering at Stanford University. Her research focus is on developi...
Serena Yeung-Levy's Profile | Stanford Profiles
Dr. Serena Yeung-Levy is an Assistant Professor of Biomedical Data Science and, by courtesy, of Computer Science and of Electrical Engineering at Stanford University. Her research focus is on developi...
Serena Yeung-Levy's Profile | Stanford Profiles
Dr. Serena Yeung-Levy is an Assistant Professor of Biomedical Data Science and, by courtesy, of Computer Science and of Electrical Engineering at Stanford University. Her research focus is on developi...
Serena Yeung-Levy's Profile | Stanford Profiles
Dr. Serena Yeung-Levy is an Assistant Professor of Biomedical Data Science and, by courtesy, of Computer Science and of Electrical Engineering at Stanford University. Her research focus is on developi...
Mitochondrial Abnormalities and Synaptic Damage in Huntington’s D...
Huntington’s disease (HD) is a fatal and pure genetic disease with a progressive loss of medium spiny neurons (MSN). HD is caused by expanded polyglu
Huntingtin Interacting Proteins Are Genetic Modifiers of Neurodeg...
Huntington's disease (HD) is a fatal neurodegenerative condition caused by expansion of the polyglutamine tract in the huntingtin (Htt) protein. Neuronal toxicity in HD is thought to be, at least in p...
Local origin of excitatory–inhibitory tuning equivalence in a cor...
The interplay between excitation and inhibition determines the fidelity of cortical representations. The receptive fields of excitatory neurons are often finely tuned to encoded features, but the prin...
Local origin of excitatory–inhibitory tuning equivalence in a cor...
The interplay between excitation and inhibition determines the fidelity of cortical representations. The receptive fields of excitatory neurons are often finely tuned to encoded features, but the prin...
Management of HD: Insight into Molecular Mechanisms and Potential...
Huntington’s disease (HD) is a rare type of hyperkinetic and neurodegenerative disorder characterized by abnormalities in cognitive, behavioral, and motor system, associated with picky degeneration of...
Management of HD: Insight into Molecular Mechanisms and Potential...
Huntington’s disease (HD) is a rare type of hyperkinetic and neurodegenerative disorder characterized by abnormalities in cognitive, behavioral, and motor system, associated with picky degeneration of...
Management of HD: Insight into Molecular Mechanisms and Potential...
Huntington’s disease (HD) is a rare type of hyperkinetic and neurodegenerative disorder characterized by abnormalities in cognitive, behavioral, and motor system, associated with picky degeneration of...
Clearance of mutant huntingtin - PMC
Mutant huntingtin (htt) carries an expanded polyglutamine (polyQ) repeat (>36 glutamines) in its N-terminal region, which leads htt to become misfolded and kill neuronal cells in Huntington disease (H...
A failure in energy metabolism and antioxidant uptake precede sym...
Huntington’s disease has been associated with a failure in energy metabolism and oxidative damage. Ascorbic acid is a powerful antioxidant highly concentrated in the brain where it acts as a messenger...
Normal and Expanded Huntington’s Disease Gene Alleles Produce Dis...
An expanded CAG trinucleotide repeat is the genetic trigger of neuronal degeneration in Huntington’s disease (HD), but its mode of action has yet to
Impaired striatal glutathione–ascorbate metabolism induces transi...
Identifying initial triggering events in neurodegenerative disorders is critical to developing preventive therapies. In Huntington’s disease (HD), hyperdopaminergia—probably triggered by the dysfuncti...
Internally organized mechanisms of the head direction sense | Nat...
Recording from population of head-direction cells across brain states, the authors provide experimental demonstration of the existence of internally organized attractor: the sequential activity of hea...